Vaccines and Variants: How Do They Work?
As of 23 June 2021, there are 14 variants of COVID-19 which are of concern or under investigation in the UK, according to the UK government. The unique profile of COVID-19 enables rapid mutation, producing variants which are more transmissible...
4 years agoVaccines and Variants: How Do They Work?
As of 23 June 2021, there are 14 variants of COVID-19 which are of concern or under investigation in the UK, according to the UK government. The unique profile of COVID-19 enables rapid mutation, producing variants which are more transmissible...
4 years ago
Strategies Implemented for New Modalities of Therapeutic Targeting: ASOs and RNAi
In 2018, the FDA approved the first small interfering RNA (siRNA) drug, patisiran, to treat a disease known as hereditary transthyretin amyloidosis. Since then, an increasing number of oligonucleotide-based drugs have reached the market, showing advantages over small molecule drugs....
4 years agoStrategies Implemented for New Modalities of Therapeutic Targeting: ASOs and RNAi
In 2018, the FDA approved the first small interfering RNA (siRNA) drug, patisiran, to treat a disease known as hereditary transthyretin amyloidosis. Since then, an increasing number of oligonucleotide-based drugs have reached the market, showing advantages over small molecule drugs....
4 years ago
Using Translational Research to Bridge the Gap Between Preclinical and Clinical Research
The disparity between animal models and clinical efficacy is compromising the safety and efficacy of therapeutic drugs. Translational research is building the bridge between preclinical studies and therapeutic treatment. Genomic techniques and non-traditional animal models are examples of translational approaches...
4 years agoUsing Translational Research to Bridge the Gap Between Preclinical and Clinical Research
The disparity between animal models and clinical efficacy is compromising the safety and efficacy of therapeutic drugs. Translational research is building the bridge between preclinical studies and therapeutic treatment. Genomic techniques and non-traditional animal models are examples of translational approaches...
4 years ago
Moving Towards Phenotypic Screening in Drug Discovery: An Interview with Prasun Mishra
Despite the technological advances, drug discovery is still a lengthy, expensive, and difficult stage in the drug development process. Screening assays are a critical part of rapidly and thoroughly analysing vast numbers of compounds for desired biochemical activity. In a...
4 years agoMoving Towards Phenotypic Screening in Drug Discovery: An Interview with Prasun Mishra
Despite the technological advances, drug discovery is still a lengthy, expensive, and difficult stage in the drug development process. Screening assays are a critical part of rapidly and thoroughly analysing vast numbers of compounds for desired biochemical activity. In a...
4 years ago
Injectable Cell Therapy to Repair Heart Failure
On Saturday 12 June 2021, Danish footballer Christian Eriksen collapsed during the EURO 2021 game against Finland after suffering a cardiac arrest. Cardiac arrest is one of the most serious heart conditions in which the heart will suddenly stop beating....
4 years agoInjectable Cell Therapy to Repair Heart Failure
On Saturday 12 June 2021, Danish footballer Christian Eriksen collapsed during the EURO 2021 game against Finland after suffering a cardiac arrest. Cardiac arrest is one of the most serious heart conditions in which the heart will suddenly stop beating....
4 years ago
Evaluating Advancements in Drug Discovery
Innovations in medicinal chemistry have seen significant developments in drug discovery techniques. From drug screening to pharmacokinetics, the industry has worked hard to optimise target identification and validation for important therapeutic developments. The latest advancements have demonstrated the value of...
4 years agoEvaluating Advancements in Drug Discovery
Innovations in medicinal chemistry have seen significant developments in drug discovery techniques. From drug screening to pharmacokinetics, the industry has worked hard to optimise target identification and validation for important therapeutic developments. The latest advancements have demonstrated the value of...
4 years ago
Another Direction for Clinical Oncology: Targeting the Anti-Inflammatory Response in Cancer
Approximately 15-20% of all cancer cases are preceded by infection, chronic inflammation, or autoimmunity at the same tissue or organ site. While inflammation is a natural response to tissue damage, chronic inflammation can become pathological. The role of inflammation in...
4 years agoAnother Direction for Clinical Oncology: Targeting the Anti-Inflammatory Response in Cancer
Approximately 15-20% of all cancer cases are preceded by infection, chronic inflammation, or autoimmunity at the same tissue or organ site. While inflammation is a natural response to tissue damage, chronic inflammation can become pathological. The role of inflammation in...
4 years ago
Targeted Protein Degradation: A Potential Tool for Discovering Druggable Targets
Drug discovery is the first step in therapeutic breakthroughs. Unfortunately, this cannot occur without target discovery - the identification and validation of druggable targets. Whether it be proteins or small molecules, discovering a ‘druggable’ biological target can be a challenge...
4 years agoTargeted Protein Degradation: A Potential Tool for Discovering Druggable Targets
Drug discovery is the first step in therapeutic breakthroughs. Unfortunately, this cannot occur without target discovery - the identification and validation of druggable targets. Whether it be proteins or small molecules, discovering a ‘druggable’ biological target can be a challenge...
4 years ago
Biobanks and EHR Data in Drug Design and Development
Over the last five years, drug design and development has evolved substantially with technological innovations. Electronic health records (EHRs) have played an important role in utilising health data on a digital platform in both preclinical and clinical studies. Biobanks have...
4 years agoBiobanks and EHR Data in Drug Design and Development
Over the last five years, drug design and development has evolved substantially with technological innovations. Electronic health records (EHRs) have played an important role in utilising health data on a digital platform in both preclinical and clinical studies. Biobanks have...
4 years ago
How Has The Covid-19 Pandemic Impacted Oncology and Clinical Operations?
As a part of Proventa’s Clinical Operations and Oncology Meeting May 2021, we organised a number of interesting keynote sessions pondering the latest innovations, challenges and strategies for the future. The morning keynote, hosted by Tanya Russel Kirkpatrick, VP Clinical...
4 years agoHow Has The Covid-19 Pandemic Impacted Oncology and Clinical Operations?
As a part of Proventa’s Clinical Operations and Oncology Meeting May 2021, we organised a number of interesting keynote sessions pondering the latest innovations, challenges and strategies for the future. The morning keynote, hosted by Tanya Russel Kirkpatrick, VP Clinical...
4 years ago