Strategies Implemented for New Modalities of Therapeutic Targeting: ASOs and RNAi
In 2018, the FDA approved the first small interfering RNA (siRNA) drug, patisiran, to treat a disease known as hereditary transthyretin amyloidosis. Since then, an increasing number of oligonucleotide-based drugs have reached the market, showing advantages over small molecule drugs....
3 years agoStrategies Implemented for New Modalities of Therapeutic Targeting: ASOs and RNAi
In 2018, the FDA approved the first small interfering RNA (siRNA) drug, patisiran, to treat a disease known as hereditary transthyretin amyloidosis. Since then, an increasing number of oligonucleotide-based drugs have reached the market, showing advantages over small molecule drugs....
3 years ago
Using Translational Research to Bridge the Gap Between Preclinical and Clinical Research
The disparity between animal models and clinical efficacy is compromising the safety and efficacy of therapeutic drugs. Translational research is building the bridge between preclinical studies and therapeutic treatment. Genomic techniques and non-traditional animal models are examples of translational approaches...
3 years agoUsing Translational Research to Bridge the Gap Between Preclinical and Clinical Research
The disparity between animal models and clinical efficacy is compromising the safety and efficacy of therapeutic drugs. Translational research is building the bridge between preclinical studies and therapeutic treatment. Genomic techniques and non-traditional animal models are examples of translational approaches...
3 years ago
Moving Towards Phenotypic Screening in Drug Discovery: An Interview with Prasun Mishra
Despite the technological advances, drug discovery is still a lengthy, expensive, and difficult stage in the drug development process. Screening assays are a critical part of rapidly and thoroughly analysing vast numbers of compounds for desired biochemical activity. In a...
3 years agoMoving Towards Phenotypic Screening in Drug Discovery: An Interview with Prasun Mishra
Despite the technological advances, drug discovery is still a lengthy, expensive, and difficult stage in the drug development process. Screening assays are a critical part of rapidly and thoroughly analysing vast numbers of compounds for desired biochemical activity. In a...
3 years ago
Injectable Cell Therapy to Repair Heart Failure
On Saturday 12 June 2021, Danish footballer Christian Eriksen collapsed during the EURO 2021 game against Finland after suffering a cardiac arrest. Cardiac arrest is one of the most serious heart conditions in which the heart will suddenly stop beating....
3 years agoInjectable Cell Therapy to Repair Heart Failure
On Saturday 12 June 2021, Danish footballer Christian Eriksen collapsed during the EURO 2021 game against Finland after suffering a cardiac arrest. Cardiac arrest is one of the most serious heart conditions in which the heart will suddenly stop beating....
3 years ago
Evaluating Advancements in Drug Discovery
Innovations in medicinal chemistry have seen significant developments in drug discovery techniques. From drug screening to pharmacokinetics, the industry has worked hard to optimise target identification and validation for important therapeutic developments. The latest advancements have demonstrated the value of...
3 years agoEvaluating Advancements in Drug Discovery
Innovations in medicinal chemistry have seen significant developments in drug discovery techniques. From drug screening to pharmacokinetics, the industry has worked hard to optimise target identification and validation for important therapeutic developments. The latest advancements have demonstrated the value of...
3 years ago
Machine Learning Data Analysis: Applications Across Immunology, Oncology and Diabetes
Computational modelling is becoming increasingly popular for data analysis in life sciences. Vast areas of therapeutic research are taking advantage of machine learning (ML) approaches for disease predictions and pathology. Cancer image analysis and diabetes case prediction are a few...
3 years agoMachine Learning Data Analysis: Applications Across Immunology, Oncology and Diabetes
Computational modelling is becoming increasingly popular for data analysis in life sciences. Vast areas of therapeutic research are taking advantage of machine learning (ML) approaches for disease predictions and pathology. Cancer image analysis and diabetes case prediction are a few...
3 years ago
Understanding the GP Data Extraction Scheme & Use of Patient Data
The General Practice Data for Planning and Research (GPDPR) is a proposed central NHS digital database collating patient data from GP records in England. Originally 1 July 2021, the date for launch has been pushed back to 1 September after...
3 years agoUnderstanding the GP Data Extraction Scheme & Use of Patient Data
The General Practice Data for Planning and Research (GPDPR) is a proposed central NHS digital database collating patient data from GP records in England. Originally 1 July 2021, the date for launch has been pushed back to 1 September after...
3 years ago
Another Direction for Clinical Oncology: Targeting the Anti-Inflammatory Response in Cancer
Approximately 15-20% of all cancer cases are preceded by infection, chronic inflammation, or autoimmunity at the same tissue or organ site. While inflammation is a natural response to tissue damage, chronic inflammation can become pathological. The role of inflammation in...
3 years agoAnother Direction for Clinical Oncology: Targeting the Anti-Inflammatory Response in Cancer
Approximately 15-20% of all cancer cases are preceded by infection, chronic inflammation, or autoimmunity at the same tissue or organ site. While inflammation is a natural response to tissue damage, chronic inflammation can become pathological. The role of inflammation in...
3 years ago
Targeted Protein Degradation: A Potential Tool for Discovering Druggable Targets
Drug discovery is the first step in therapeutic breakthroughs. Unfortunately, this cannot occur without target discovery - the identification and validation of druggable targets. Whether it be proteins or small molecules, discovering a ‘druggable’ biological target can be a challenge...
3 years agoTargeted Protein Degradation: A Potential Tool for Discovering Druggable Targets
Drug discovery is the first step in therapeutic breakthroughs. Unfortunately, this cannot occur without target discovery - the identification and validation of druggable targets. Whether it be proteins or small molecules, discovering a ‘druggable’ biological target can be a challenge...
3 years ago
Biobanks and EHR Data in Drug Design and Development
Over the last five years, drug design and development has evolved substantially with technological innovations. Electronic health records (EHRs) have played an important role in utilising health data on a digital platform in both preclinical and clinical studies. Biobanks have...
3 years agoBiobanks and EHR Data in Drug Design and Development
Over the last five years, drug design and development has evolved substantially with technological innovations. Electronic health records (EHRs) have played an important role in utilising health data on a digital platform in both preclinical and clinical studies. Biobanks have...
3 years ago